Z-VAD(OMe)-FMK
| Name | Z-VAD(OMe)-FMK |
|---|---|
| Supplier | Cell Signaling Technology |
| Catalog | 60332 |
| Prices | $139.00 |
| Sizes | 1 mg |
| Formula | C22H30FN3O7 |
| Molecular Weight | 467.5 g/mol |
| Purity | >95% |
| Description | The synthetic peptide Z-VAD(OMe)-FMK is a cell permeable, irreversible pan-caspase inhibitor that displays non-cytotoxic effects (1-4). Z-VAD(OMe)-FMK prevents caspase-3 from adopting its active form and thereby blocks apoptosis (5). Research studies show that Z-VAD(OMe)-FMK also inhibits other enzymes, including cathepsin B, PNGase, and picornaviral 2A proteinases (6-8). Additional studies demonstrate that Z-VAD(OMe)-FMK can inhibit mitogen-induced T cell proliferation (2,9,10). |
| Supplier Page | Shop |
Product images
Western blot analysis of extracts from Jurkat cells, untreated (-) or treated with Etoposide #2200 (25 μM, 5 hr; +), either with or without Z-VAD(OMe)-FMK pretreatment (1 hr) at the indicated concentrations, using Cleaved Caspase-8 (Asp391) (18C8) Rabbit mAb #9496, Caspase-8 (1C12) Mouse mAb #9746, Cleaved PARP (Asp214) (D64E10) XP ® Rabbit mAb #5625, and PARP (46D11) Rabbit mAb #9532.
Chemical structure of Z-VAD(OMe)-FMK.