AV 412

• Supplier: Tocris Bioscience
• Catalog: 5959
• Prices: $299.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 451492-95-8
• Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-2-propenamide
• Formula: C27H28ClFN6O
• Molecular Weight: 507
• Purity: >98 %
• Description: Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases (IC 50 values are 0.5-2, 19 and 41 nM, respectively). Also weak inhibitor of FLT1 and Src. Inhibits EGFR and ErbB2 autophosphorylation in vitro in NSCLC and T-47D breast cancer cell lines, respectively. Inhibits tumor growth of EGFR-overexpressing A431 and ErbB2 overexpressing BT-474 tumor xenografts in mice.