AZ 628

• Supplier: Tocris Bioscience
• Catalog: 5775
• Prices: $219.00, $905.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 878739-06-1
• Chemical Name: 3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide
• Formula: C27H25N5O2
• Molecular Weight: 451.52
• Purity: >98 %
• Description: Potent, ATP-competitive inhibitor of Raf kinases (IC 50 values are 29, 34 and 105 nM for c-Raf1, B-Raf V600E and wild-type B-Raf, respectively). Displays selectivity for Raf kinases over a panel of 150 other kinases; inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-Raf V600E mutation.