BIRT 377

• Supplier: Tocris Bioscience
• Catalog: 5989
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 213211-10-0
• Chemical Name: (5R)-5-[(4-Bromophenyl)methyl]-3-(3,5-dichlorophenyl)-1,5-dimethyl-2,4-imidazolidinedione
• Formula: C18H15BrCl2N2O2
• Molecular Weight: 442.13
• Purity: >98 %
• Description: Potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (K d = 26 nM). Binds to the I-domain of LFA-1. Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. Inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo . Orally available.