G-15

• Supplier: Tocris Bioscience
• Catalog: 5944
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1161002-05-6
• Chemical Name: (3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline
• Formula: C19H16BrNO2
• Molecular Weight: 370.24
• Purity: >99 %
• Description: High affinity and selective GPER receptor antagonist (K i = 20 nM) that displays no affinity for ER α and ER β at concentrations up to 10 μ M. Inhibits agonist-induced calcium mobilization in vitro (EC 50 of ~185 nM) and antagonizes the antidepressive and renoprotective effects of estrogen in vivo .