Perifosine

Name Perifosine
Supplier Tocris Bioscience
Catalog 5166
Prices $95.00, $399.00
Sizes 10 mg, 50 mg
Function Type Inhibitor
Cas Number 157716-52-4
Chemical Name Octadecyl-(1,1-dimethyl-4-piperidylio)phosphate
Formula C25H52NO4P
Molecular Weight 461.66
Purity >99 %
Description PKB/Akt inhibitor; accumulates in and reorganizes lipid rafts disrupting Akt signaling. Also inhibits MAPK pathway and induces autophagy. Induces apoptosis in leukemia cell lines. Decreases K v 2.1 current amplitude by modulating its inactivation gating. Antitumor. Orally bioavailable.
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