| Name | PF 05175157 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 6003 |
| Prices | $149.00, $629.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1301214-47-0 |
| Chemical Name | 1,4-Dihydro-1'-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one |
| Formula | C23H27N5O2 |
| Molecular Weight | 405.49 |
| Purity | >98 % |
| Description | Acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC 50 values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepatic de novo lipogenesis and reduces whole body respiratory exchange ratio in rats. Orally bioavailable. |
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