| Name | PF 06409577 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 6004 |
| Prices | $159.00, $669.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Activator |
| Cas Number | 1467057-23-3 |
| Chemical Name | 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylicacid |
| Formula | C19H16ClNO3 |
| Molecular Weight | 341.79 |
| Purity | >98 % |
| Description | Potent and selective allosteric activator of AMPK (EC 50 values are 7 and >40000 nM for AMPK α 1 β 1 γ 1 and AMPK α 1 β 2 γ 1, respectively). Exhibits minimal off target effects on a panel of receptors, ion channels, PDEs and kinases. Demonstrates efficacy in a preclinical model of diabetic nephropathy. Orally bioavailable. |
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