AMG 548

• Supplier: Tocris Bioscience
• Catalog: 5995
• Prices: $249.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 864249-60-5
• Chemical Name: 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone
• Formula: C29H27N5O
• Molecular Weight: 461.56
• Purity: >98 %
• Description: Potent and selective inhibitor of p38 α (K i values are 0.5, 3.6, 2600 and 4100 nM for p38 α , p38 β , p38 γ and p38 δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNF α (IC 50 = 3 nM) . Efficacious in acute and chronic models of arthritis.