Axitinib

• Supplier: Tocris Bioscience
• Catalog: 5843
• Prices: $229.00, $945.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 319460-85-0
• Chemical Name: N-Methyl-[[3[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-benzamide
• Formula: C22H18N4OS
• Molecular Weight: 386.47
• Purity: >99 %
• Description: Potent inhibitor of VEGFR-2, -3, and -1 (IC 50 values are 0.2, 0.1-0.3, and 1.2 nM respectively). Exhibits minimal activity against a panel of ~100 protein kinase. Inhibits angiogenesis and vascular permeability. Also a high affinity BCR-ABL1 (T315I) inhibitor (K i = 149 pM for autophosphorylated ABL1 (T315I)). Blocks proliferation of Ba/F3 cells expressing BCR-ABL1 (T315I). Orally available.