AZD 1480

• Supplier: Tocris Bioscience
• Catalog: 6085
• Prices: $235.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 935666-88-9
• Chemical Name: 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidine-2,4-diamine
• Formula: C14H14ClFN8
• Molecular Weight: 348.77
• Purity: >98 %
• Description: Potent and selective JAK2 inhibitor (IC 50 < 3 nM). Exhibits >50-fold selectivity for JAK2 over JAK3. Exhibits antitumor effects and inhibits formation of lung metastases in a mouse renal cancer model. Also inhibits STAT3 signaling, tumor angiogenesis and myeloid cell migration in vivo .