BI 78D3

• Supplier: Tocris Bioscience
• Catalog: 5300
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 883065-90-5
• Chemical Name: 4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2,4-dihydro-5-[(5-nitro-2-thiazolyl)thio]-3H-1,2,4-triazol-3-one
• Formula: C13H9N5O5S2
• Molecular Weight: 379.37
• Purity: >99 %
• Description: Competitive c-Jun N-terminal kinase (JNK) inhibitor (IC 50 = 280 nM) that displays > 100 fold selectivity over p38α and no activity at mTOR and PI-3K. Inhibits JNK interacting protein 1 (JIP1)-JNK binding (IC 50 = 500 nM) and prevents JNK substrate phosphorylation. Blocks JNK-dependent Con A-induced liver damage and restores insulin sensitivity in a mouse model of type II diabetes.