| Name | Echinomycin |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5955 |
| Prices | $105.00 |
| Sizes | 1 mg |
| Function Type | Inhibitor |
| Cas Number | 512-64-1 |
| Chemical Name | N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic(37)-thioether |
| Formula | C51H64N12O12S2 |
| Molecular Weight | 1101.26 |
| Purity | >98 % |
| Description | Highly potent and selective HIF-1 α inhibitor (IC 50 = 29.4 pM). Selectively inhibits HIF-1 binding to the VEGF promoter without affecting the binding of AP-1 or NF- κ B. Inhibits colony formation of cancer stem cells (CSC) with a 100-fold selectivity over normal hematopoietic progenitor cells. Eradicates mouse lymphomas and human AML xenografts by eliminating CSCs. |
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