HBX 41108

• Supplier: Tocris Bioscience
• Catalog: 4991
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 924296-39-9
• Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
• Formula: C13H3ClN4O
• Molecular Weight: 266.64
• Purity: >98 %
• Description: Inhibitor of ubiquitin-specific protease (USP) 7 activity (IC 50 = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC 50 = 0.8 μ M). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.