| Name | ME 0328 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5785 |
| Prices | $189.00, $765.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1445251-22-8 |
| Chemical Name | 3,4-Dihydro-4-oxo-3,4-Dihydro-4-oxo-N-[(1S)-1-phenylethyl]-2-quinazolinepropanamide |
| Formula | C19H19N3O2 |
| Molecular Weight | 321.37 |
| Purity | >98 % |
| Description | Inhibitor of PARP-3 (IC 50 = 0.89 μ M). Displays selectivity for PARP-3 over PARP-1, PARP-2 and other ARDT enzymes (IC 50 values are 6.3, 10.8 and >30 μ M respectively). Enhances CRISPR-Cas9-mediated HER2 mutation frequency, resulting in increased reduction in proliferation of HER2-positive breast cancer cells. Cell permeable. |
| Supplier Page | Shop |