| Name | MM 102 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 6171 |
| Prices | $245.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Chemical Name | 1-[[(2S)-5-[(Aminoiminomethyl)amino]-2-[[2-ethyl-2-[(2-methyl-1-oxopropyl)amino]-1-oxobutyl]amino]-1-oxopentyl]amino]-N-[bis(4-fluorophenyl)methyl]-cyclopentanecarboxamidetrifluoroacetate |
| Formula | C35H49F2N7O4.CF3CO2H |
| Molecular Weight | 783.83 |
| Purity | >98 % |
| Description | Potent WDR5/MLL interaction inhibitor (IC 50 = 2.4 nM). Inhibits MLL1 methyltransferase activity and MLL-1-induced HoxA9 and Meis-1 gene expression in leukemia cells expressing the MLL1-AF9 fusion gene. Also inhibits cell growth and induces apoptosis in leukemia cells harbouring MLL1 fusion proteins. |
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