NCX 4040

• Supplier: Tocris Bioscience
• Catalog: 5934
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Cas Number: 287118-97-2
• Chemical Name: 2-(Acetyloxy)benzoicacid4-[(nitrooxy)methyl]phenylester
• Formula: C16H13NO7
• Molecular Weight: 331.28
• Purity: >98 %
• Description: NO-donating aspirin; anti-inflammatory. Blocks inflammatory mediator production in isolated human monocytes (IC 50 values are 0.07, 0.13, 0.15 and 0.18 μ M for IL-1 β , PGE 2 , IL-10 and TNF- α respectively). Decreases COX-2 expression (IC 50 = 0.13 μ M); disrupts proteasome-mediated degradation of i κ B- α . Antiproliferative in HCT116 colon cancer cells; sensitizes drug-resistant ovarian tumor cells to cisplatin (Cat. No. 2251).