| Name | PF 06281355 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 6115 |
| Prices | $155.00, $655.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1435467-38-1 |
| Chemical Name | 6-(2,5-Dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-1(2H)-pyrimidineacetamide |
| Formula | C14H15N3O4S |
| Molecular Weight | 321.35 |
| Purity | >98 % |
| Description | Selective myeloperoxidase (MPO) inhibitor (IC 50 = 1.5 μ M in LPS-stimulated human whole blood). Selective for MPO over a panel of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibits MPO activity in peritoneal lavage and plasma in a murine peritonitis model. Also reduces lung edema in a murine pulmonary immune complex vasculitis model. Orally bioavailable. |
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