Ro 3306

• Supplier: Tocris Bioscience
• Catalog: 5968
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 872573-93-8
• Chemical Name: 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
• Formula: C18H13N3OS2
• Molecular Weight: 351.45
• Purity: >98 %
• Description: ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (K i values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively). Induces G 2 /M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML).