TPCA-1

• Supplier: Tocris Bioscience
• Catalog: 5999
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 507475-17-4
• Chemical Name: 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
• Formula: C12H10FN3O2S
• Molecular Weight: 279.29
• Purity: >97 %
• Description: Potent, selective inhibitor of I κ B kinase (IKK) β (IC 50 = 17.9 nM) that displays > 22-fold selectivity over IKK α and > 550-fold selectivity over other kinases and enzymes. Inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF- κ B nuclear localization. Reduces the severity and onset of collagen-induced arthritis; anti-inflammatory.