| Name | LY2157299 |
|---|---|
| Supplier | BioGems |
| Catalog | 7007224 |
| Prices | $175.00, $755.00 |
| Sizes | 5 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 700874-72-2 |
| Chemical Name | 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide |
| Formula | C22H19N5O |
| Molecular Weight | 369.4 |
| Purity | ≥98% |
| Description | LY2157299 is a potent inhibitor of Transforming Growth factor-Beta Receptor I (TGF-BetaR). TGF-Beta1 is involved in the control of cell growth, proliferation, differentiation, and apoptosis. LY2157299 is reported to disrupt Smad-2 phosphorylation in Human Umbilical Vein Endothelial Cells (HUVEC) and inhibit the growth and migration of tumor cells. |
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