U0126

• Supplier: BioGems
• Catalog: 1095821
• Prices: $145.00, $560.00
• Sizes: 5 mg, 25 mg
• Function Type: Inhibitor
• Cas Number: 109511-58-2
• Chemical Name: (2Z,3Z)-2,3-bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile
• Formula: C18H16N6S2
• Molecular Weight: 380.5
• Purity: ≥98%
• Description: U0126 is a highly selective inhibitor of MEK1 (IC50 of 72nM) and MEK2 (IC50 of 58nM) that antagonizes AP-1 transcriptional activity. U0216 helps maintain human pluripotent stem cells in the undifferentiated state. It is also reported to sensitize cells to anoikis, as upon treatment with U0126 cells deprived of anchorage enter apoptosis.