AIM 100

• Supplier: Tocris Bioscience
• Catalog: 6161
• Function Type: Inhibitor
• Cas Number: 873305-35-2
• Chemical Name: 5,6-Diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]furo[2,3-d]pyrimidin-4-amine
• Formula: C23H21N3O2
• Molecular Weight: 371.43
• Purity: >98 %
• Description: Potent Ack1 (TNK2) inhibitor (IC 50 = 22 nM). Exhibits selectivity for Ack1 over ABL1, BTK, Lck and LYN; exhibits no inhibition of 25 other kinases. Suppresses phosphorylation of Tyr267 of the androgen receptor in prostate cancer cells. Also suppresses growth of radioresistant castration-resistant prostate cancer in xenograft tumors in mice.