Enzastaurin

• Supplier: Tocris Bioscience
• Catalog: 6234
• Function Type: Inhibitor
• Cas Number: 170364-57-5
• Chemical Name: 3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione
• Formula: C32H29N5O2
• Molecular Weight: 515.6
• Purity: >98 %
• Description: Potent PKC β inhibitor (IC 50 values are 6, 39, 83 and 110 nM for PKC β , PKC α , PKC γ and PKC ε , respectively). Suppresses proliferation and induces apoptosis in HCT116 colon carcinoma and U87MG glioblastoma cells in vitro . Reduces tumor growth and exhibits antiangiogenic activity in HT-29 colon carcinoma xenografts in mice. Also suppresses growth of HCT116 and U87MG xenografts in mice. Orally active.