| Name | Ex 26 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 6188 |
| Function Type | Antagonist |
| Cas Number | 1233332-37-0 |
| Chemical Name | 1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylicacid |
| Formula | C28H28ClFN2O3 |
| Molecular Weight | 494.98 |
| Purity | >98 % |
| Description | Potent and selective S1P 1 receptor antagonist (IC 50 = 0.93 nM). Exhibits > 3,000-fold selectivity for S1P 1 over S1P 2 , S1P 3 , S1P 4 and S1P 5 . Induces lymphocyte sequestration in peripheral lymph nodes and upregulates S1P 1 receptor expression. Reduces disease severity in mice with EAE. Increases IFN- α production in stimulated dendritic cells in vivo . |
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