LDN 214117

• Supplier: Tocris Bioscience
• Catalog: 6151
• Function Type: Inhibitor
• Cas Number: 1627503-67-6
• Chemical Name: 1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine
• Formula: C25H29N3O3
• Molecular Weight: 419.52
• Purity: >98 %
• Description: Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptor ALK2 (IC 50 = 24 nM). Shows preference for ALK1 and ALK2 over ALK3 and 164-fold selectivity for BMP6 inhibition (IC 50 = 100 nM) over TGF-β1. Exhibits improved kinome selectivity over K 02288 (Cat.No. 4986) and low cytotoxicity.