MS 436

• Supplier: Tocris Bioscience
• Catalog: 6208
• Function Type: Inhibitor
• Cas Number: 1395084-25-9
• Chemical Name: (E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
• Formula: C18H17N5O3S
• Molecular Weight: 383.42
• Purity: >98 %
• Description: Potent and selective BRD4 bromodomain inhibitor (K i = 30 - 50 nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC 50 values are 3.8 and 4.9 μ M, respectively). Attenuates melanoma cell proliferation in vitro .