Reversan

• Supplier: Tocris Bioscience
• Catalog: 6190
• Function Type: Inhibitor
• Cas Number: 313397-13-6
• Chemical Name: N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
• Formula: C26H27N5O2
• Molecular Weight: 441.52
• Purity: >99 %
• Description: Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo . Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.