Ribavirin

• Supplier: Tocris Bioscience
• Catalog: 6168
• Cas Number: 36791-04-5
• Chemical Name: 1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
• Formula: C8H12N4O5
• Molecular Weight: 244.2
• Purity: >99 %
• Description: Antiviral guanosine ribonucleoside analog; misincorporated into mRNA by viral-dependent RNA polymerases. Binds to and redistributes mammalian eIF4E from the nucleus to the cytoplasm (K i ~ 0.3 μ M for the active metabolite, ribavirin triphosphate). Represses colony formation of primary AML-M5 progenitor cells (IC 50 ~ 1 μ M); reduces disease severity in acute myeloid leukemia (AML). Orally available.