SKI II

• Supplier: Tocris Bioscience
• Catalog: 5452
• Function Type: Inhibitor
• Cas Number: 312636-16-1
• Chemical Name: 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol
• Formula: C15H11ClN2OS
• Molecular Weight: 302.78
• Purity: >98 %
• Description: Selective non-lipid inhibitor of sphingosine kinase (IC 50 = 0.5 μ M); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKC α at concentrations up to 60 μ M. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC 50 = 0.9 - 4.6 μ M).