TASP 0433864

• Supplier: Tocris Bioscience
• Catalog: 5729
• Function Type: Modulator
• Cas Number: 1431980-60-7
• Chemical Name: (2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide
• Formula: C18H23N3O3
• Molecular Weight: 329.39
• Purity: >98 %
• Description: Selective mGlu 2 receptor positive allosteric modulator (EC 50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT 2B and MAO-B (72 and 92% inhibition at 10 μ M, respectively). Potentiates inhibitory effect of DCG IV (Cat. No. 0975) on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.