| Name | TMCB |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 6194 |
| Function Type | Inhibitor |
| Cas Number | 905105-89-7 |
| Chemical Name | 2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)aceticacid |
| Formula | C11H9Br4N3O2 |
| Molecular Weight | 534.82 |
| Purity | >98 % |
| Description | Dual-kinase inhibitor; inhibits both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8) (IC 50 = 0.50 μ M for both CK2 and ERK8). Displays selectivity for CK2 over protein kinases normally susceptible to CK2 inhibitors (K i values are 0.25, 8.65, 11.90 and 15.25 μ M for CK2, PIM1, DYRK1a and HIPK2 respectively). |
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