XMD 8-92

• Supplier: Tocris Bioscience
• Catalog: 6061
• Function Type: Inhibitor
• Cas Number: 1234480-50-2
• Chemical Name: 2-[[2-Ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,11-dihydro-5,11-dimethyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
• Formula: C26H30N6O3
• Molecular Weight: 474.55
• Purity: >98 %
• Description: ERK5 (BMK1) and BRD4 inhibitor (K d values are 80 and 190 nM, respectively). Also inhibits DCAMKL2, PLK4 and TNK1 (K d values are 190, 600 and 890 nM). Blocks growth factor-induced activation of cellular BMK1 and reduces BMK1 activity in in vitro kinase assays. Also reduces BMK1-dependent transactivating activity of MEF2C. Inhibits proliferation in a variety of cancer cell lines; blocks tumor cell proliferation and tumor-associated angiogenesis.