LDH-A Inhibitor III, NHI-1 - CAS 1269802-68-7 - Calbiochem

• Supplier: EMD Millipore
• Catalog: 533966
• Cas Number: 1269802-68-7
• Formula: C₁₆H₁₀F₃NO₃
• Purity: ≥98% by HPLC
• Description: A cell-permeable, noncytotoxic NHI (N-hydroxyindole) carboxylate that acts as an isoform A-selective LDH inhibitor (87% inhibition of hLDH-A 4 vs 11% inhibition of hLDH-B 4 at 125 µM; [NADH] = 25 µM & [pyruvate] = 2 mM) in a competitive manner with respect to both NADH ( K i = 8.9 µM; [pyruvate] = 2 mM) and pyruvate ( K i = 4.7 µM; [NADH] = 200 µM)