Dyngo® 4a
| Name | Dyngo® 4a |
|---|---|
| Supplier | Abcam |
| Catalog | ab120689 |
| Cas Number | 1256493-34-1 |
| Chemical Name | 3-Hydroxy-N'-[(2,4,5-trihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide |
| Formula | C18H14N2O5 |
| Molecular Weight | 338.31 |
| Description | Novel, highly potent dynamin inhibitor. Dynasore (ab120192) analog. |
| Supplier Page | Shop |
Product images
ab66705 staining PAI1 in HeLa cells treated with dyngo-4a™(ab120689), by ICC/IF. Increase in PAI1 expression correlates with increased concentration of dyngo-4a™, as described in literature.The cells were incubated at 37°C for 6h in media containing different concentrations of ab120689 (dyngo-4a™) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab66705 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Product References
Spatially restricted G protein-coupled receptor activity via divergent endocytic - Spatially restricted G protein-coupled receptor activity via divergent endocytic
Jean-Alphonse F, Bowersox S, Chen S, Beard G, Puthenveedu MA, Hanyaloglu AC. J Biol Chem. 2014 Feb 14;289(7):3960-77.
Uptake of Helicobacter pylori vesicles is facilitated by clathrin-dependent and - Uptake of Helicobacter pylori vesicles is facilitated by clathrin-dependent and
Olofsson A, Nygard Skalman L, Obi I, Lundmark R, Arnqvist A. MBio. 2014 May 20;5(3):e00979-14.
Conformational biosensors reveal GPCR signalling from endosomes. - Conformational biosensors reveal GPCR signalling from endosomes.
Irannejad R, Tomshine JC, Tomshine JR, Chevalier M, Mahoney JP, Steyaert J, Rasmussen SG, Sunahara RK, El-Samad H, Huang B, von Zastrow M. Nature. 2013 Mar 28;495(7442):534-8.
Host cell entry of respiratory syncytial virus involves macropinocytosis followed - Host cell entry of respiratory syncytial virus involves macropinocytosis followed
Krzyzaniak MA, Zumstein MT, Gerez JA, Picotti P, Helenius A. PLoS Pathog. 2013;9(4):e1003309.
Building a better dynasore: the dyngo compounds potently inhibit dynamin and - Building a better dynasore: the dyngo compounds potently inhibit dynamin and
McCluskey A, Daniel JA, Hadzic G, Chau N, Clayton EL, Mariana A, Whiting A, Gorgani NN, Lloyd J, Quan A, Moshkanbaryans L, Krishnan S, Perera S, Chircop M, von Kleist L, McGeachie AB, Howes MT, Parton RG, Campbell M, Sakoff JA, Wang X, Sun JY, Robertson MJ, Deane FM, Nguyen TH, Meunier FA, Cousin MA, Robinson PJ. Traffic. 2013 Dec;14(12):1272-89.
Rapid synaptic vesicle endocytosis in cone photoreceptors of salamander retina. - Rapid synaptic vesicle endocytosis in cone photoreceptors of salamander retina.
Van Hook MJ, Thoreson WB. J Neurosci. 2012 Dec 12;32(50):18112-23.
Acid-activated structural reorganization of the Rift Valley fever virus Gc fusion - Acid-activated structural reorganization of the Rift Valley fever virus Gc fusion
de Boer SM, Kortekaas J, Spel L, Rottier PJ, Moormann RJ, Bosch BJ. J Virol. 2012 Dec;86(24):13642-52.
Caveolae, fenestrae and transendothelial channels retain PV1 on the surface of - Caveolae, fenestrae and transendothelial channels retain PV1 on the surface of
Tkachenko E, Tse D, Sideleva O, Deharvengt SJ, Luciano MR, Xu Y, McGarry CL, Chidlow J, Pilch PF, Sessa WC, Toomre DK, Stan RV. PLoS One. 2012;7(3):e32655.