Dynole® 34-2
| Name | Dynole® 34-2 |
|---|---|
| Supplier | Abcam |
| Catalog | ab120463 |
| Pubchem | 44157463 |
| Chemical Name | 2-Cyano-N-octyl-3-[1-(3-dimethylaminopropyl)-1H-indol-3-yl]acrylamide |
| Formula | C25H36N4O |
| Molecular Weight | 408.59 |
| Purity | > 98% |
| Description | Potent dynamin I and dynamin II inhibitor |
| Supplier Page | Shop |
Product images
ab66705 staining PAI1 in HeLa cells treated with dynole-34-2™; (ab120463), by ICC/IF. Increase in PAI1 expression correlates with increased concentration of dynole-34-2™, as described in literature.The cells were incubated at 37°C for 24h in media containing different concentrations of ab120463 (dynole-34-2™) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab66705 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Product References
Intracellular curvature-generating proteins in cell-to-cell fusion. - Intracellular curvature-generating proteins in cell-to-cell fusion.
Richard JP, Leikina E, Langen R, Henne WM, Popova M, Balla T, McMahon HT, Kozlov MM, Chernomordik LV. Biochem J. 2011 Dec 1;440(2):185-93.
Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but - Inhibition of HIV-1 endocytosis allows lipid mixing at the plasma membrane, but
de la Vega M, Marin M, Kondo N, Miyauchi K, Kim Y, Epand RF, Epand RM, Melikyan GB. Retrovirology. 2011 Dec 6;8:99.