GsMTx-4
| Name | GsMTx-4 |
|---|---|
| Supplier | Abcam |
| Catalog | ab141871 |
| Chemical Name | GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF (Modifications: Phe-34 = C-terminal amide, Disulfide bridges: 2-17, 9-23 and 16-30) |
| Formula | C185H273N49O45S6 |
| Molecular Weight | 4095.85 |
| Purity | > 98% |
| Description | Mechanosensitive and stretch-activated ion channel inhibitor |
| Supplier Page | Shop |
Product images
GsMTx-4 inhibits NaV1.7 channel currents expressed in Xenopus oocytes. NaV1.7 currents were elicited by 100 ms voltage ramp from a holding potential of -100 mV to +30 mV, applied every 10 sec using whole-cell voltage clamp technique. Left: Superimposed traces of NaV1.7 currents before (black) and during (green) application of 500 nM GsMTx-4 (ab141871). Right: GsMTx-4 dose response inhibition of NaV1.7 currents.