GYKI 52466
| Name | GYKI 52466 |
|---|---|
| Supplier | Abcam |
| Catalog | ab120336 |
| Cas Number | 102771-26-6 |
| Pubchem | 10042240 |
| Chemical Name | 4-(8-Methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-benzenamine hydrochloride |
| Formula | C17H15N3O2.HCl |
| Molecular Weight | 329.79 |
| Purity | > 99% |
| Description | Selective non-competitive AMPA antagonist |
| Supplier Page | Shop |
Product images
ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with GYKI 52466 (ab120336), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of GYKI 52466, as described in literature.The cells were incubated at 37°C for 1h in media containing different concentrations of ab120336 (GYKI 52466) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.
Product References
Cocaine-taking and cocaine-seeking behaviors in rats remain stable after systemic - Cocaine-taking and cocaine-seeking behaviors in rats remain stable after systemic
Srivastava R, Xi ZX, Gardner EL. Neurosci Lett. 2012 Feb 6;508(2):106-9.
Striatal dopamine transmission is subtly modified in human A53Talpha-synuclein - Striatal dopamine transmission is subtly modified in human A53Talpha-synuclein
Platt NJ, Gispert S, Auburger G, Cragg SJ. PLoS One. 2012;7(5):e36397.
Striatal dopamine release is triggered by synchronized activity in cholinergic - Striatal dopamine release is triggered by synchronized activity in cholinergic
Threlfell S, Lalic T, Platt NJ, Jennings KA, Deisseroth K, Cragg SJ. Neuron. 2012 Jul 12;75(1):58-64.
Application of an optogenetic byway for perturbing neuronal activity via glial - Application of an optogenetic byway for perturbing neuronal activity via glial
Sasaki T, Beppu K, Tanaka KF, Fukazawa Y, Shigemoto R, Matsui K. Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20720-5. doi:
Striatal muscarinic receptors promote activity dependence of dopamine - Striatal muscarinic receptors promote activity dependence of dopamine
Threlfell S, Clements MA, Khodai T, Pienaar IS, Exley R, Wess J, Cragg SJ. J Neurosci. 2010 Mar 3;30(9):3398-408.