Huwentoxin-IV
| Name | Huwentoxin-IV |
|---|---|
| Supplier | Abcam |
| Catalog | ab141873 |
| Chemical Name | ECLEIFKACNPSNDQCCKSSKLVCSRKTRWCKYQI (Modifications: Ile-35 = C-terminal amide, Disulfide bridges: 2-17, 9-24 and 16-31) |
| Formula | C174H278N55O51S6 |
| Molecular Weight | 4106.00 |
| Purity | > 99% |
| Description | Neuronal tetrodotoxin (TTX) -sensitive voltage-gated Na+ channel inhibitor |
| Supplier Page | Shop |
Product images
Huwentoxin-IV inhibits NaV1.7 channels heterologously expressed in Xenopus oocytes. A. Time course of current inhibition by 500 nM Huwentoxin-IV (ab141873) (green). Currents were elicited by a voltage ramp between -80 mV to +20 mV (60 ms) every 10 seconds from holding potential of -80 mV. B. Example traces of current response to voltage ramp application before (black) and during (green) 500 nM Huwentoxin-IV application.