ICI 182,780
| Name | ICI 182,780 |
|---|---|
| Supplier | Abcam |
| Catalog | ab120131 |
| Cas Number | 129453-61-8 |
| Pubchem | 17756771 |
| Chemical Name | (7R,9S,13S,14S,17S)-7-(9-(4,4,5,5,5-Pentafluoropentylsulfinyl)nonyl)-7,8,9,11,12,13,14,15,16,17-decahydro-13-methyl-6H-cyclopenta[a]phenanthrene-3,17-diol |
| Formula | C32H47F5O3S |
| Molecular Weight | 606.77 |
| Purity | > 99% |
| Description | Estrogen receptor antagonist |
| Supplier Page | Shop |
Product images
ab47489 staining BCL2 in MCF7 cells treated with ICI 182,780 (ab120131), by ICC/IF. Decrease in BCL2 expression correlates with increased concentration of ICI 182,780 as described in literature.The cells were incubated at 37°C for 3h in media containing different concentrations of ab120131 (ICI 182,780) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab47489 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Product References
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Xiao L, Chang AK, Zang MX, Bi H, Li S, Wang M, Xing X, Wu H. PLoS One. 2014 May 2;9(5):e95878.
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Schennink A, Trott JF, Freking BA, Hovey RC. J Mol Endocrinol. 2013 May 9;51(1):1-13.