KN-62
| Name | KN-62 |
|---|---|
| Supplier | Abcam |
| Catalog | ab120421 |
| Cas Number | 127191-97-3 |
| Pubchem | 5312126 |
| Chemical Name | 4-[(2S)-2-[(5-Isoquinolinylsulfonyl)methylamino]-3-oxo-3-(4-phenyl-1-piperazinyl)propyl] phenylisoquinolinesulfonic acid ester |
| Formula | C38H35N5O6S2 |
| Molecular Weight | 721.84 |
| Purity | > 98% |
| Description | CaM kinase II inhibitor. P2X7 antagonist. |
| Supplier Page | Shop |
Product images
ab18197 staining PCNA in SK-N-SH cells treated with KN-62 (ab120421), by ICC/IF. Increase in PCNA nuclear expression correlates with increased concentration of KN-62, as described in literature.The cells were incubated at 37°C for 24h in media containing different concentrations of ab120421 (KN-62) in DMSO, fixed with 100% methanol for 5 minutes at -20°C and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18197 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Product References
Developmental switch in the kinase dependency of long-term potentiation depends - Developmental switch in the kinase dependency of long-term potentiation depends
Luchkina NV, Huupponen J, Clarke VR, Coleman SK, Keinanen K, Taira T, Lauri SE. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4321-6. doi:
Developmental switch in the kinase dependency of long-term potentiation depends - Developmental switch in the kinase dependency of long-term potentiation depends
Luchkina NV, Huupponen J, Clarke VR, Coleman SK, Keinanen K, Taira T, Lauri SE. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4321-6. doi: