Kynurenic acid
| Name | Kynurenic acid |
|---|---|
| Supplier | Abcam |
| Catalog | ab120064 |
| Cas Number | 492-27-3 |
| Pubchem | 3845 |
| Chemical Name | 4-Hydroxyquinoline-2-carboxylic acid |
| Formula | C10H7NO3 |
| Molecular Weight | 189.17 |
| Purity | > 99% |
| Description | Endogenous ionotropic / nicotinic antagonist |
| Supplier Page | Shop |
Product images
C1 and C2 - Inhibition of climbing fiber to Purkinje cell EPSCs in (control; black) by 1 mM Kynurenic acid (red, ab120064) or 100 nM NBQX (green, ab120045) recorded in 2.5 mM external Ca2+ at 0.05 Hz (C1) and 2 Hz (C2) stimulation frequency. D - Summary of inhibition of EPSCs by 1 mM Kynurenic acid (red, ab120064) and 100 nM NBQX (green, ab120045) in 2.5 mM external Ca2+.
Product References
Tonic inhibition of accumbal spiny neurons by extrasynaptic alpha4betadelta GABAA - Tonic inhibition of accumbal spiny neurons by extrasynaptic alpha4betadelta GABAA
Maguire EP, Macpherson T, Swinny JD, Dixon CI, Herd MB, Belelli D, Stephens DN, King SL, Lambert JJ. J Neurosci. 2014 Jan 15;34(3):823-38.
Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral - Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral
Kupchik YM, Scofield MD, Rice KC, Cheng K, Roques BP, Kalivas PW. J Neurosci. 2014 Jan 15;34(3):1057-66.
Endogenous zinc depresses GABAergic transmission via T-type Ca(2+) channels and - Endogenous zinc depresses GABAergic transmission via T-type Ca(2+) channels and
Grauert A, Engel D, Ruiz AJ. J Physiol. 2014 Jan 1;592(Pt 1):67-86.
Glutamate and dopamine transmission from midbrain dopamine neurons share similar - Glutamate and dopamine transmission from midbrain dopamine neurons share similar
Adrover MF, Shin JH, Alvarez VA. J Neurosci. 2014 Feb 26;34(9):3183-92.
Glutamate and dopamine transmission from midbrain dopamine neurons share similar - Glutamate and dopamine transmission from midbrain dopamine neurons share similar
Adrover MF, Shin JH, Alvarez VA. J Neurosci. 2014 Feb 26;34(9):3183-92.
Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through - Diurnal inhibition of NMDA-EPSCs at rat hippocampal mossy fibre synapses through
Perin M, Longordo F, Massonnet C, Welker E, Luthi A. J Physiol. 2014 Oct 1;592(Pt 19):4277-95.
Strengthening the accumbal indirect pathway promotes resilience to compulsive - Strengthening the accumbal indirect pathway promotes resilience to compulsive
Bock R, Shin JH, Kaplan AR, Dobi A, Markey E, Kramer PF, Gremel CM, Christensen CH, Adrover MF, Alvarez VA. Nat Neurosci. 2013 May;16(5):632-8.
Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic - Dysfunctional astrocytic and synaptic regulation of hypothalamic glutamatergic
Gunn BG, Cunningham L, Cooper MA, Corteen NL, Seifi M, Swinny JD, Lambert JJ, Belelli D. J Neurosci. 2013 Dec 11;33(50):19534-54.
Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus - Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus
Christian CA, Huguenard JR. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20278-83. doi:
Acid-sensing ion channel-1a is not required for normal hippocampal LTP and - Acid-sensing ion channel-1a is not required for normal hippocampal LTP and
Wu PY, Huang YY, Chen CC, Hsu TT, Lin YC, Weng JY, Chien TC, Cheng IH, Lien CC. J Neurosci. 2013 Jan 30;33(5):1828-32.