LY 294002
| Name | LY 294002 |
|---|---|
| Supplier | Abcam |
| Catalog | ab120243 |
| Cas Number | 154447-36-6 |
| Pubchem | 3973 |
| Chemical Name | 2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one |
| Formula | C19H17NO3 |
| Molecular Weight | 307.35 |
| Purity | > 99% |
| Description | PI3-kinase inhibitor |
| Supplier Page | Shop |
Product images
Performed under reducing conditions; Samples loaded at 30 µg/lane. Membrane blocking and secondary antibody incubation performed in 5% milk/PBST. Primary antibody incubation performed in 5% BSA/PBST. Lane 1: Marker Lane 2: A431 lysate starved Lane 3: A431 lysate starved treated with 100 ng/mL of EGF for 30 min Lane 4: A431 lysate starved and pretreated for 2 hours with 10µM U0126 (ab120241) Lane 5: A431 lysate starved and pretreated for 2 hours with 30µM Ly294002 (ab120243) Primary: AKT/MAPK signaling pathway antibody cocktail at 1/250 dilution Secondary: HRP conjugated Goat anti-Rabbit secondary antibody at 1:10,000 dilution. Observed bands: RSK1p90 (pS380) band size: 83 kDa AKT1 (pS473) band size: 56 kDa ERK1 (pY204) and ERK2 (pY187) band size: 43 kDa RPS6 (pS235/236) band size: 31 kDa Rab11a band size: 24 kDa Unknown band: 130kDa
Product References
High glucose-induced resistance to 5-fluorouracil in pancreatic cancer cells - High glucose-induced resistance to 5-fluorouracil in pancreatic cancer cells
Cheng Y, Diao D, Zhang H, Guo Q, Wu X, Song Y, Dang C. Biomed Rep. 2014 Mar;2(2):188-192. Epub 2013 Dec 9.
Lymphocyte-mediated neuroprotection in in vitro models of excitotoxicity involves - Lymphocyte-mediated neuroprotection in in vitro models of excitotoxicity involves
Shrestha R, Millington O, Brewer J, Dev KK, Bushell TJ. Neuropharmacology. 2014 Jan;76 Pt A:184-93. doi:
Regulation and function of Cav3.1 T-type calcium channels in IGF-I-stimulated - Regulation and function of Cav3.1 T-type calcium channels in IGF-I-stimulated
Pluteanu F, Cribbs LL. Am J Physiol Cell Physiol. 2011 Mar;300(3):C517-25. doi: