MPEP hydrochloride

• Supplier: Abcam
• Catalog: ab120008
• Cas Number: 96206-92-7
• Pubchem: 9794588
• Chemical Name: 2-Methyl-6-(phenylethynyl)pyridine hydrochloride
• Formula: C14H11N.HCl
• Molecular Weight: 229.71
• Purity: > 99%
• Description: Potent, selective mGlu5 antagonist

Product images

Astrocyte Ca2+ signal inhibition does not affect interictal discharges. (A–D) Mean percentage of astrocytes activated by the ictal discharges (A), mean duration (B) and frequency (C) of the ictal discharge, and mean frequency of interictal discharges (D) under different experimental conditions in EC slice preparations. Controls (n=16), MPEP (ab120008) (n=7), PPADS (ab120009) (n=9), and MPEP+PPADS (n=3). A single asterisk (*) indicates p<0.05; double asterisks (**), p<0.01.

Ca2+ signal from a field A neuron, a field B neuron, and field A astrocytes in response to repetitive episodes of NMDA stimulation (black arrowheads). The NMDA stimulation that evoked an ictal discharge became ineffective after blocking the astrocyte response by bath perfusion with MPEP (ab120008) and PPADS (ab120009). An ictal discharge could be recovered by increasing the number of NMDA puffs (white arrowheads). A double NMDA pulse evoked both astrocyte activation and the ictal discharge after inhibitor washout.

Product References

Epileptiform stimulus increases Homer 1a expression to modulate synapse number - Epileptiform stimulus increases Homer 1a expression to modulate synapse number

Li Y, Popko J, Krogh KA, Thayer SA. J Neurophysiol. 2013 Mar;109(6):1494-504.

Astrocyte signaling controls spike timing-dependent depression at neocortical - Astrocyte signaling controls spike timing-dependent depression at neocortical

Min R, Nevian T. Nat Neurosci. 2012 Mar 25;15(5):746-53.

CREB-dependent transcriptional control and quantal changes in persistent - CREB-dependent transcriptional control and quantal changes in persistent

Ran I, Laplante I, Lacaille JC. J Neurosci. 2012 May 2;32(18):6335-50.

Switching off LTP: mGlu and NMDA receptor-dependent novelty exploration-induced - Switching off LTP: mGlu and NMDA receptor-dependent novelty exploration-induced

Qi Y, Hu NW, Rowan MJ. Cereb Cortex. 2013 Apr;23(4):932-9.

Excitatory modulation in the cochlear nucleus through group I metabotropic - Excitatory modulation in the cochlear nucleus through group I metabotropic

Chanda S, Xu-Friedman MA. J Neurosci. 2011 May 18;31(20):7450-5.

Enhancement of CA3 hippocampal network activity by activation of group II - Enhancement of CA3 hippocampal network activity by activation of group II

Ster J, Mateos JM, Grewe BF, Coiret G, Corti C, Corsi M, Helmchen F, Gerber U. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9993-7. doi:

Purinergic signaling in the cerebellum: Bergmann glial cells express functional - Purinergic signaling in the cerebellum: Bergmann glial cells express functional

Habbas S, Ango F, Daniel H, Galante M. Glia. 2011 Dec;59(12):1800-12.

Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue - Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue

Krishnan B, Genzer KM, Pollandt SW, Liu J, Gallagher JP, Shinnick-Gallagher P. PLoS One. 2011;6(9):e25639.

Regulation of increased glutamatergic input to spinal dorsal horn neurons by - Regulation of increased glutamatergic input to spinal dorsal horn neurons by

Li JQ, Chen SR, Chen H, Cai YQ, Pan HL. J Neurochem. 2010 Jan;112(1):162-72.

An excitatory loop with astrocytes contributes to drive neurons to seizure - An excitatory loop with astrocytes contributes to drive neurons to seizure

Gomez-Gonzalo M, Losi G, Chiavegato A, Zonta M, Cammarota M, Brondi M, Vetri F, Uva L, Pozzan T, de Curtis M, Ratto GM, Carmignoto G. PLoS Biol. 2010 Apr 13;8(4):e1000352.