NBQX disodium salt
| Name | NBQX disodium salt |
|---|---|
| Supplier | Abcam |
| Catalog | ab120046 |
| Cas Number | 118876-58-7 |
| Pubchem | 3272523 |
| Chemical Name | 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt |
| Formula | C12H6N4Na2O6S |
| Molecular Weight | 380.24 |
| Purity | > 98% |
| Description | AMPA / kainate antagonist; water soluble |
| Supplier Page | Shop |
Product images
ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with NBQX disodium salt (ab120046), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of NBQX disodium salt, as described in literature.The cells were incubated at 37°C for 24h in media containing different concentrations of ab120046 (NBQX disodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.
Product References
The N-terminal domain modulates - The N-terminal domain modulates
Moykkynen T, Coleman SK, Semenov A, Keinanen K. J Biol Chem. 2014 May 9;289(19):13197-205.
Activation of the mTOR signaling pathway in the antidepressant-like activity of - Activation of the mTOR signaling pathway in the antidepressant-like activity of
Palucha-Poniewiera A, Szewczyk B, Pilc A. Neuropharmacology. 2014 Jul;82:59-68.
Activation of calcineurin underlies altered trafficking of alpha2 subunit - Activation of calcineurin underlies altered trafficking of alpha2 subunit
Eckel R, Szulc B, Walker MC, Kittler JT. Neuropharmacology. 2015 Jan;88:82-90.
Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid - Synaptic Zn2+ inhibits neurotransmitter release by promoting endocannabinoid
Perez-Rosello T, Anderson CT, Schopfer FJ, Zhao Y, Gilad D, Salvatore SR, Freeman BA, Hershfinkel M, Aizenman E, Tzounopoulos T. J Neurosci. 2013 May 29;33(22):9259-72.
SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking - SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking
Chamberlain SE, Gonzalez-Gonzalez IM, Wilkinson KA, Konopacki FA, Kantamneni S, Henley JM, Mellor JR. Nat Neurosci. 2012 Jun;15(6):845-52.
Calcium influx measured at single presynaptic boutons of cerebellar granule cell - Calcium influx measured at single presynaptic boutons of cerebellar granule cell
Zhang W, Linden DJ. Cerebellum. 2012 Mar;11(1):121-31.
Neurotransmitter release at the thalamocortical synapse instructs barrel - Neurotransmitter release at the thalamocortical synapse instructs barrel
Narboux-Neme N, Evrard A, Ferezou I, Erzurumlu RS, Kaeser PS, Laine J, Rossier J, Ropert N, Sudhof TC, Gaspar P. J Neurosci. 2012 May 2;32(18):6183-96.
On the mechanism of the antidepressant-like action of group II mGlu receptor - On the mechanism of the antidepressant-like action of group II mGlu receptor
Palucha-Poniewiera A, Wieronska JM, Branski P, Stachowicz K, Chaki S, Pilc A. Psychopharmacology (Berl). 2010 Dec;212(4):523-35. doi:
Mapping the ligand binding sites of kainate receptors: molecular determinants of - Mapping the ligand binding sites of kainate receptors: molecular determinants of
Atlason PT, Scholefield CL, Eaves RJ, Mayo-Martin MB, Jane DE, Molnar E. Mol Pharmacol. 2010 Dec;78(6):1036-45.
Early development of the thalamic inhibitory feedback loop in the primary - Early development of the thalamic inhibitory feedback loop in the primary
Evrard A, Ropert N. J Neurosci. 2009 Aug 5;29(31):9930-40.