Paxilline
| Name | Paxilline |
|---|---|
| Supplier | Abcam |
| Catalog | ab141840 |
| Cas Number | 57186-25-1 |
| Pubchem | 105008 |
| Chemical Name | (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2'',3'':5',6']benz[1',2':6,7]indeno[1,2-b]indol-3(4bH)-one |
| Formula | C27H33NO4 |
| Molecular Weight | 435.60 |
| Purity | > 98% |
| Description | Potent high-conductance Ca2+-activated K+channel blocker |
| Supplier Page | Shop |
Product images
Paxilline inhibits KCa1.1 (BK) channels heterologously expressed in Xenopus oocytes. Left: The effect of 100 nM Paxilline (ab141840) (a), Penitrem A (ab141842) (P-650) (b), and Verruculogen (ab141889) (c) on BK currents. Time course of current amplitude changes upon sequential application of the three toxins. Right: Example of current responses to 100 ms depolarization before (red) and during (black) perfusion of 500 nM Paxilline.