PD 98059
| Name | PD 98059 |
|---|---|
| Supplier | Abcam |
| Catalog | ab120234 |
| Cas Number | 167869-21-8 |
| Pubchem | 4713 |
| Chemical Name | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one |
| Formula | C16H13NO3 |
| Molecular Weight | 267.28 |
| Purity | > 99% |
| Description | MEK1 inhibitor |
| Supplier Page | Shop |
Product images
ab18195 staining hnRNP K in HeLa cells treated with PD 98059 (ab120234), by ICC/IF. Changes in localization of hnRNP K (translocation from cytoplasm to nucleous) correlates with increased concentration of hnRNP K, as described in literature.The cells were incubated at 37°C for 24h in media containing different concentrations of ab120234 ( hnRNP K) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18195 (5 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody. Nuclei were counterstained with DAPI and are shown in blue.
Product References
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Wang MJ, Li YC, Snyder MA, Wang H, Li F, Gao WJ. PLoS One. 2013 Apr 12;8(4):e61787.
Regulation and function of Cav3.1 T-type calcium channels in IGF-I-stimulated - Regulation and function of Cav3.1 T-type calcium channels in IGF-I-stimulated
Pluteanu F, Cribbs LL. Am J Physiol Cell Physiol. 2011 Mar;300(3):C517-25. doi:
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Baxter PS, Martel MA, McMahon A, Kind PC, Hardingham GE. J Neurochem. 2011 Aug;118(3):365-78.