PPADS
| Name | PPADS |
|---|---|
| Supplier | Abcam |
| Catalog | ab120009 |
| Cas Number | 149017-66-3 |
| Chemical Name | 4-[[4-Formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-1,3-benzenedisulfonic acid tetrasodium salt |
| Formula | C14H10N3Na4O12PS2 |
| Molecular Weight | 599.30 |
| Description | P2 purinergic receptor antagonist |
| Supplier Page | Shop |
Product images
Astrocyte Ca2+ signal inhibition does not affect interictal discharges. (A–D) Mean percentage of astrocytes activated by the ictal discharges (A), mean duration (B) and frequency (C) of the ictal discharge, and mean frequency of interictal discharges (D) under different experimental conditions in EC slice preparations. Controls (n=16), MPEP (ab120008) (n=7), PPADS (ab120009) (n=9), and MPEP+PPADS (n=3). A single asterisk (*) indicates p<0.05; double asterisks (**), p<0.01.
Ca2+ signal from a field A neuron, a field B neuron, and field A astrocytes in response to repetitive episodes of NMDA stimulation (black arrowheads). The NMDA stimulation that evoked an ictal discharge became ineffective after blocking the astrocyte response by bath perfusion with MPEP (ab120008) and PPADS (ab120009). An ictal discharge could be recovered by increasing the number of NMDA puffs (white arrowheads). A double NMDA pulse evoked both astrocyte activation and the ictal discharge after inhibitor washout.
Product References
Purine receptor-mediated endocannabinoid production and retrograde synaptic - Purine receptor-mediated endocannabinoid production and retrograde synaptic
Kovacs FE, Illes P, Szabo B. Br J Pharmacol. 2011 Feb;162(4):974-88.
P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin. - P2X4 receptors in activated C8-B4 cells of cerebellar microglial origin.
Toulme E, Garcia A, Samways D, Egan TM, Carson MJ, Khakh BS. J Gen Physiol. 2010 Apr;135(4):333-53.
An excitatory loop with astrocytes contributes to drive neurons to seizure - An excitatory loop with astrocytes contributes to drive neurons to seizure
Gomez-Gonzalo M, Losi G, Chiavegato A, Zonta M, Cammarota M, Brondi M, Vetri F, Uva L, Pozzan T, de Curtis M, Ratto GM, Carmignoto G. PLoS Biol. 2010 Apr 13;8(4):e1000352.