Ryanodine
| Name | Ryanodine |
|---|---|
| Supplier | Abcam |
| Catalog | ab120083 |
| Cas Number | 15662-33-6 |
| Chemical Name | 1H-Pyrrole-2-carboxylic acid (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2] pentaleno[1,6-bc]furan-8-yl ester |
| Formula | C25H35NO9 |
| Molecular Weight | 493.55 |
| Purity | > 98% |
| Description | Ca2+ release modulator |
| Supplier Page | Shop |
Product images
Ryanodine inhibits the elevation of intracellular Ca2+ by PI(3,5)P2 in primary cardiac myocytes. Top figure shows fura-2 ratiometric changes in intracellular Ca2+ in an isolated ventricular adult cardiac myocyte after treatment with PI(3,5)P2, ultimately resulting in contraction. Bottom figure shows that ryanodine inhibited the release of SR Ca2+ to both caffeine and PI(3,5)P2.
Product References
Role of ion channels and subcellular Ca2+ signaling in arachidonic acid-induced - Role of ion channels and subcellular Ca2+ signaling in arachidonic acid-induced
Kur J, McGahon MK, Fernandez JA, Scholfield CN, McGeown JG, Curtis TM. Invest Ophthalmol Vis Sci. 2014 May 2;55(5):2893-902.
Functional ryanodine receptors in the membranes of neurohypophysial secretory - Functional ryanodine receptors in the membranes of neurohypophysial secretory
McNally JM, Custer EE, Ortiz-Miranda S, Woodbury DJ, Kraner SD, Salzberg BM, Lemos JR. J Gen Physiol. 2014 Jun;143(6):693-702.
Ca(2+) signals evoked by histamine H1 receptors are attenuated by activation of - Ca(2+) signals evoked by histamine H1 receptors are attenuated by activation of
Pantazaka E, Taylor EJ, Bernard WG, Taylor CW. Br J Pharmacol. 2013 Aug;169(7):1624-34.
Ca(2+) signals evoked by histamine H1 receptors are attenuated by activation of - Ca(2+) signals evoked by histamine H1 receptors are attenuated by activation of
Pantazaka E, Taylor EJ, Bernard WG, Taylor CW. Br J Pharmacol. 2013 Aug;169(7):1624-34.
Distribution and Ca(2+) signalling of fibroblast-like (PDGFR(+)) cells in the - Distribution and Ca(2+) signalling of fibroblast-like (PDGFR(+)) cells in the
Baker SA, Hennig GW, Salter AK, Kurahashi M, Ward SM, Sanders KM. J Physiol. 2013 Dec 15;591(Pt 24):6193-208.
Hydrogen sulphide inhibits Ca2+ release through InsP3 receptors and relaxes - Hydrogen sulphide inhibits Ca2+ release through InsP3 receptors and relaxes
Castro-Piedras I, Perez-Zoghbi JF. J Physiol. 2013 Dec 1;591(Pt 23):5999-6015.
Selective facilitation of LTP in the ventral hippocampus by calcium stores. - Selective facilitation of LTP in the ventral hippocampus by calcium stores.
Grigoryan G, Korkotian E, Segal M. Hippocampus. 2012 Jul;22(7):1635-44.
Structural and functional conservation of key domains in InsP3 and ryanodine - Structural and functional conservation of key domains in InsP3 and ryanodine
Seo MD, Velamakanni S, Ishiyama N, Stathopulos PB, Rossi AM, Khan SA, Dale P, Li C, Ames JB, Ikura M, Taylor CW. Nature. 2012 Jan 29;483(7387):108-12.
Distinct contributions by ionotropic purinoceptor subtypes to ATP-evoked calcium - Distinct contributions by ionotropic purinoceptor subtypes to ATP-evoked calcium
Bhattacharya S, Verrill DS, Carbone KM, Brown S, Yule DI, Giovannucci DR. J Physiol. 2012 Jun 1;590(Pt 11):2721-37.
Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate - Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate
Westcott EB, Goodwin EL, Segal SS, Jackson WF. J Physiol. 2012 Apr 15;590(Pt 8):1849-69.