Tetrodotoxin

• Supplier: Abcam
• Catalog: ab120054
• Cas Number: 4368-28-9
• Chemical Name: Octahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d] pyrimidine-4,7,10,11,12-pentol
• Formula: C11H17N3O8
• Molecular Weight: 319.27
• Purity: > 98%
• Description: Na+ channel blocker

Product images

TTX blocked the ictal discharge in both field A and B neurons, but not the direct response of field A neurons to a double NMDA pulse (black arrowheads).

Multiple connections between CA3 and CA1 pyramidal cells and GABAergic cells and CA1 pyramidal cells in young adult rats. (A1) A typical recording at -80 mV from a pyramidal cell, upper trace shows AMPA sEPSCs under control conditions and lower trace shows mEPSCs after wash-in of TTX. (A2) TTX reduces the AMPA EPSC amplitude by 5.9 ± 0.8 pA (P = 0.004, n = 8, two-tailed paired t-test). (A3) TTX reduces AMPA EPSC frequency by 1.5 ± 0.4 Hz (P < 0.001, n = 8, one-tailed paired t-test). (A4) The average multiplicity was 1.7 ± 0.1 (P < 0.001, n = 8, one-tailed one-sample t-test with test value = 1). (B1) A typical recording at 0 mV from a pyramidal cell, upper trace shows GABA sIPSCs under control conditions and lower trace shows mIPSCs after wash-in of TTX. (B2) TTX reduces the GABA IPSC amplitude by 8.4 ± 2.7 pA (P = 0.03, n = 6, two-tailed paired t-test). (B3) TTX reduces GABA IPSC frequency by 3.2 ± 0.8 Hz (P = 0.005, n = 6, one-tailed paired t-test). (B4) The average multiplicity was 2

Product References

Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor - Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor

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The endogenous peptide antisecretory factor promotes tonic GABAergic signaling in - The endogenous peptide antisecretory factor promotes tonic GABAergic signaling in

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Endogenous zinc depresses GABAergic transmission via T-type Ca(2+) channels and - Endogenous zinc depresses GABAergic transmission via T-type Ca(2+) channels and

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Mg2+ block properties of triheteromeric GluN1-GluN2B-GluN2D NMDA receptors on - Mg2+ block properties of triheteromeric GluN1-GluN2B-GluN2D NMDA receptors on

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The inflammatory molecules IL-1beta and HMGB1 can rapidly enhance focal seizure - The inflammatory molecules IL-1beta and HMGB1 can rapidly enhance focal seizure

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